The Intimidators took the lead in the second and never looked back, scoring two runs on a Brandon Dulin (4) two run home run.
Kannapolis added another in the fourth on a Joel Booker RBI single and two more in the eighth on a Seby Zavala (5) two run home run.
Rome scored one in the eight on a passed ball, but felt short in the 5-1 final.
Alec Hansen (3-3) earns the victory for Kannapolis while Bryce Wilson (2-1) takes the loss for Rome.
Rome is off today and will play host to the Lexington Legends for a 4-game set Thursday-Sunday at State Mutual Stadium.